GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | trans | rs1056667 | 1 | rs1884946 | chr6:26545308 | ZNF322B | chr9:99957633-99961910:- | 0.54 | 10.32 | 1.14E-22 | Educational attainment |
| THCA | trans | rs1056667 | 1 | rs1884948 | chr6:26567988 | ZNF322B | chr9:99957633-99961910:- | 0.59 | 11.41 | 7.49E-27 | Educational attainment |
| THCA | trans | rs1056667 | 1 | rs1884949 | chr6:26568067 | ZNF322B | chr9:99957633-99961910:- | 0.59 | 11.37 | 1.09E-26 | Educational attainment |
| THCA | trans | rs766432 | 1 | rs1896295 | chr2:60724086 | HBG1 | chr11:5269502-5271087:- | -0.45 | -6.35 | 4.9E-10 | Beta thalassemia/hemoglobin E disease;F-cell distribution;Fetal hemoglobin levels;Hemoglobin A2 levels in sickle cell anemia;Sickle cell anemia (haemolysis) |
| THCA | trans | rs766432 | 1 | rs1896296 | chr2:60724087 | HBG1 | chr11:5269502-5271087:- | -0.45 | -6.54 | 1.57E-10 | Beta thalassemia/hemoglobin E disease;F-cell distribution;Fetal hemoglobin levels;Hemoglobin A2 levels in sickle cell anemia;Sickle cell anemia (haemolysis) |
| THCA | trans | rs853679 | 1 | rs1936365 | chr6:28268452 | BTN3A2 | chr6:26365398-26378546:+ | 0.46 | 9.05 | 3.49E-18 | Depression |
| THCA | trans | rs7122488 | 1 | rs1945360 | chr11:21846314 | AKR7L | chr1:19592476-19600568:- | 0.33 | 5.93 | 5.77E-9 | Attention function in attention deficit hyperactive disorder |
| THCA | trans | rs41266839 | 1 | rs1979 | chr6:26377591 | RNF5P1 | chr8:38457695-38458775:- | 0.57 | 6.18 | 1.39E-9 | Schizophrenia |
| THCA | trans | rs41266839 | 1 | rs1979 | chr6:26377591 | ZFP57 | chr6:29640171-29648887:- | 0.53 | 6 | 3.99E-9 | Schizophrenia |
| THCA | trans | rs6600671 | 1 | rs1986111 | chr1:121204788 | NBPF14 | chr1:148003643-148346791:- | 0.44 | 10.38 | 6.72E-23 | Hip geometry |
| THCA | trans | rs199307 | 1 | rs199307 | chr20:15177580 | MACROD2 | chr20:13976146-16033839:+ | 0.4 | 7.13 | 3.61E-12 | Obesity-related traits |
| THCA | trans | rs2084385 | 1 | rs2084385 | chr3:196553867 | LOC646214 | chr15:21932514-21940739:- | -0.47 | -6.21 | 1.19E-9 | Total ventricular volume (Alzheimer's disease interaction) |
| THCA | trans | rs2084385 | 1 | rs2084386 | chr3:196554020 | LOC646214 | chr15:21932514-21940739:- | -0.55 | -6.47 | 2.44E-10 | Total ventricular volume (Alzheimer's disease interaction) |
| THCA | trans | rs6600671 | 1 | rs2185281 | chr1:121179991 | NBPF14 | chr1:148003643-148346791:- | 0.42 | 10.02 | 1.45E-21 | Hip geometry |
| THCA | trans | rs1056667 | 1 | rs2208331 | chr6:26507319 | ZNF322B | chr9:99957633-99961910:- | 0.55 | 10.32 | 1.08E-22 | Educational attainment |